Two-tailed t-test **p<0.01 DAPI, 4’,6-diamidino-2-phenylindole; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HC, healthy control; MDM, monocyte-derived macrophage; PBMCs, peripheral blood mononuclear cells; SEM, standard error of the mean; WAS, Wiskott Aldrich syndrome. The gene discussed is GAPDH; the disease is Wiskott-Aldrich syndrome.