PIK3CA and cancer: Phosphorylation of eIF4E (S209) (p-4E, thereafter) and its inhibitor 4E-BP1 (i.e. T37/T46, S65/T70) is elevated in a variety of cancers due to activated RAS/RAF/ERK and PI3K/AKT/mTOR signaling (Martineau et al., 2013).