Isogenic CRC cells (HCT116, Lim1215 and SW48) harboring mutant KRAS (G13D or G12V) showed higher basal levels of p-ERK, p-4E/4E-BP1, p-eIF2α and Myc, and are more sensitive to Gln deprivation, compared to their KRAS wildtype counterparts (Figure 6A–B). The gene discussed is EIF2A; the disease is colorectal carcinoma.