Accordingly, we sought to elucidate the precise relationships among HCV infection, RBP4, and IR by conducting a prospective CHC cohort study analyzing the profiles before and after anti-HCV therapy, as comparing the pre- and post-therapy profiles within the same patients with sustained virological responses (SVRs) has provided an excellent opportunity to eliminate the individual bias affecting RBP4 levels [9–12]. The gene discussed is RBP4; the disease is cryohydrocytosis.