Interestingly, the HCMV-encoded chemokine receptor US28 increases the stabilization of HIF-1α via a Gq protein alpha subunit- (Gαq), calcium/calmodulin-dependent protein kinase II- (CaMKII) and AKT/mTOR-dependent manner, which supports the notion that HCMV infection may be favored by HIF-1 activation [83] Figure 2. This evidence concerns the gene HIF1A and cytomegalovirus infection.