There is also evidence indicating that these oncoproteins -especially E6 and E7- promote the expression of vascular endothelial growth factor (VEGF) and other angiogenesis factors, such as IL-8, which can promote tumor angiogenesis via a HIF-1α/VEGF pathway in non-small cell lung cancers and human cervical carcinoma cells [63]. This evidence concerns the gene HIF1A and neoplasm.