Another study on mice with IBD indicated that berberine reduced the production of TNF‐α, IL‐12, IL‐6 and TGF‐β in the maturated DCs and thereby decreased the population of Th1/Th17 cells in the mesenteric lymph nodes (MLNs), resulting in the amelioration of colon inflammation in colitis‐induced mice.95 This evidence concerns the gene TGFB1 and colitis.