Anomalous autoreactive responses of CD4+ T helper cells, such as Th1 cells producing IFNγ 2 and Th17 cells producing IL‐17,47, 48, 49, 50, 51, 52 are tightly correlated with the clinical severity and progression of several autoimmune diseases, clinically and experimentally.11, 12, 53, 54. This evidence concerns the gene CD4 and autoimmune disease.