To further investigate the function of DEPDC1B in PCa tumorigenesis in vivo, stable DEPDC1B‐overexpressing, DEPDC1B‐silenced, or control PC3 cells were subcutaneously injected into BALB/c nude mice, and the features of the tumors were measured every 3 days. This evidence concerns the gene DEPDC1B and posterior cortical atrophy.