It is our novel discovery that DEPDC1B induces EMT and promotes the mobility and proliferation of PCa via Rac1‐PAK1 signaling pathway by interacting with Rac1.Therefore, our findings provide insight into DEPDC1B and indicate that Rac1 might be an important treatment target against mPCa (Figure 8D). The gene discussed is DEPDC1B; the disease is posterior cortical atrophy.