After treatment with NSC23766‐specific or Rac1‐specific siRNAs, E‐cadherin, and claudin1 were increased while N‐cadherin, snail, slug, and β‐catenin were reduced in DEPDC1B‐overexpressing PCa cells, which indicated inhibition of the EMT process (Figure 8A and B). This evidence concerns the gene RAC1 and posterior cortical atrophy.