To explore whether DEPDC1B regulates PCa cell in Rac1 dependent manner, we overexpressed DEPDC1B and then used an inhibitor of Rac1‐GTP (NSC23766) to inhibit Rac1 specific activation and siRNAs to knockdown the expression of Rac1 in PCa cells. The gene discussed is RAC1; the disease is posterior cortical atrophy.