We showed that, when inhibited by I‐BET151, BRD4 significantly downregulates Notch1/NICD/Hes1 expression in a dose‐dependent manner, and the BRD4 depletion groups showed the same result (Figure 3B and C), neither BRD2 nor BRD3 interfered with Notch1, NICD, and Hes1 expressions in GBM cells (Supporting information Figure S4A‐C). Here, HES1 is linked to glioblastoma.