RNF43 and colorectal carcinoma: In a recent study, by analyzing the genomic data from TCGA, CRC-associated gene alterations including BrafV600E, Cdkn2a, Tgfbr2, Znrf2 and Rnf43, were selected to be introduced into murine colon organoids using CRISPR-Cas9 technology to model the serrated pathway (Lannagan et al. 2019).