Phosphorylation levels of TnI and MyBP-C are decreased in idiopathic DCM58,59 and normal in a number of human DCM samples with mutations in thin-filament protein genes (TNNI3, TNNT2, TNNC1),59,60 but reduced in DCM samples with TTNtv (Figure 1D). The gene discussed is TNNI3; the disease is familial dilated cardiomyopathy.