The level of phosphorylation of MyBP-C and MYL2 in DCM samples with TTNtv was 0.62 ± 0.18 vs. 1.55 ± 0.08 mol Pi/mol MyBP-C (P < 0.001; four patient and 17 donor hearts, respectively; Figure 1D) and 0.06 ± 0.11 vs. 0.18 ± 0.02 mol Pi/mol MYL2 (P < 0.05; four patient and 16 donor hearts, respectively; Figure 1D). This evidence concerns the gene MYBPC3 and familial dilated cardiomyopathy.