Our data showed that TERTp mutations were significantly associated with EGFR amp/gain, CDKN2A deletion, and PTEN deletion and were typically found in IDH wild-type GBM; conversely, the TERTp wild type was associated with PDGFR amp/gain, CDK4 gain, and TP53 deletion. This evidence concerns the gene CDK4 and glioblastoma.