ApoE4 genotype had a substantial gene dose main effect on MMSE and ADAS score associating with worse cognitive performance (Tables 2 and 3, Fig. 3 and Supplementary 7.16 and 8.16), as well as an association with substantially accelerated cognitive decline (Tables 2 and 3, Fig. 3 and Supplementary 7.16 and 8.16). This evidence concerns the gene APOE and Mental deterioration.