Several studies have also found that ApoE4 alleles are associated with accelerated cognitive decline and accelerated cortical tissue atrophy (Kanai et al., 1999; Tilvis et al., 2004; Bartzokis et al., 2006; Morra et al., 2009; Whitehair et al., 2010; Lo et al., 2011; Mielke et al., 2011; Young et al., 2014; Vijayaraghavan et al., 2016; Kim et al., 2017; Rawle et al., 2018). This evidence concerns the gene APOE and Mental deterioration.