Changes in IP-10 and TNF-RII levels were associated with worsening of general fatigue (Figure 2A and Table 3; P = 0.03 and P = .02, respectively), and statistically significant associations were observed between insomnia and CRP, IFN-r, IFN-α2a, IL-17A, IP-10, and TNF-RII (Table 3; P < .05 for all). This evidence concerns the gene TNF and insomnia measurement.