von Willebrand disease (VWD) represents one of the most common inherited hemorrhagic disorders in France with 1,980 patients identified in the FranceCoag network in December 2016.1The disease results from genetic defects generally localized in the von Willebrand factor (VWF) gene, defects that can either modify the function of the protein or affect its clearance and/or synthesis. This evidence concerns the gene VWF and Von Willebrand disease.