VWF and von Willebrand disease (hereditary or acquired): In conclusion, VWF mutational analysis can be valuable for diagnosing and investigating the molecular etiology of VWD.4The prediction softwares used (SpliceSiteFinder-like, MaxEntScan, GeneSplicer, NSPLICE, ESEFinder, RESCUE-ESE, and EX-SKIP) regarding c.1530G > A (p.(Val510 = )) interpreted the appearance of a donor site at 6 base pairs at the end of exon 13 which could potentially alter splicing.