Immunotherapy, specifically immune checkpoint inhibition, has been considered a useful treatment option for HCC, evidenced by both pembrolizumab (anti-PD-1) and nivolumab (anti-PD-1) with or without ipilimumab (anti-CTLA4) approved as second line therapy, and atezolizumab (anti-PD-L1) with bevacizumab approved as first line treatment options. This evidence concerns the gene CD274 and hepatocellular carcinoma.