Proteins found in HCC currently being investigated as targets in CAR-T cell research in early stage studies include GPC3 (NCT02905188, NCT03084380, NCT03130712, NCT03198546, and NCT03302403), AFP (NCT03349255), EpCAM (NCT03013712), c-Met/PD-L1 (NCT03672305), MUC-1 (NCT03198546), and DR5, c-Met or EGFRvIII (NCT03638206). This evidence concerns the gene AFP and hepatocellular carcinoma.