Of these, cluster 1 mainly included AGE-RAGE signaling pathway in diabetic complications (p = 5.30E−25), fluid shear stress and atherosclerosis (p = 7.46E−19), TNF signaling pathway (p = 6.04E−15), and IL-17 signaling pathway (p = 1.30E−14). The gene discussed is TNF; the disease is atherosclerosis.