As observed in the results of KEGG enrichment analysis, some signaling pathways (such as AGE-RAGE signaling pathway in diabetic, IL-17signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, type II diabetes, endocrine resistance, and insulin resistance signaling pathways) are closely related to the development and metastasis of T2DM. Here, TNF is linked to type 2 diabetes mellitus.