For example, in hepatocellular carcinoma, RFS is adversely affected by downregulated levels of METTL14 expression [13], while a reduction in m6A mRNA methylation caused by the METTL14 loss-of-function R298P mutation increases the proliferation and tumorigenicity of endometrial cancer cells [34]. The gene discussed is METTL14; the disease is hepatocellular carcinoma.