In multiple logistic regression analysis, independent predictors of METTL14 expression in breast cancer included higher tumor grade (odds ratio (OR) = 0.494, 95%confidence interval (CI): 0.289–0.844; P = 0.010), the presence of the TNBC subtype (OR = 0.109, 95% CI: 0.054–0.222; P < 0.001), and the presence of the HER2-enriched subtype (OR = 0.298, 95% CI: 0.156–0.567; P < 0.001). The gene discussed is ERBB2; the disease is neoplasm.