To evaluate cell damage induced by DOX, we measured the B-type natriuretic peptide (BNP) and A-type natriuretic peptide(ANP) levels 7 d after DOX administration and found that the mRNA levels of BNP and ANP were significantly increased in DOX-treated mice, indicating obvious heart failure (Figure 1(g), Supplementary Figure 1d). The gene discussed is NPPA; the disease is heart failure.