Among these 8 genes, high expression of CD5, ITGA2B, and TNFRSF13B indicated a favorable prognosis, while high expression of CD3E, CD40LG, TNFRSF4, CD3G, and ABCB1 were poor prognostic factors for HNSCC. The gene discussed is TNFRSF4; the disease is head and neck squamous cell carcinoma.