ROR2 in disease has been largely studied in the context of tumors, where WNT5A/ROR2 signaling leads to activation of calpain-mediated cleavage, cytoskeletal rearrangement for purposes of migration, and as a hypoxia-inducible factor downstream of VHL/HIF signaling with implications in tumor invasiveness and metastasis (29, 48, 49). This evidence concerns the gene ROR2 and neoplasm.