Of note, conflicting reports from both SARS and COVID-19 patients, as well as from various cell culture systems productively infected, show differences in IFN and cytokine induction, which may reflect differences in patient cohorts/cell lines, as well as in temporal analysis and assay sensitivity (Frieman et al., 2008; Guo et al., 2020). The gene discussed is IFNA1; the disease is COVID-19.