OT mediated by OXTR has been shown to improve social symptoms in autism, reduce anxiety, and induce long-term potentiation in the rodent brain through CREB phosphorylation via activation of c-Raf/MEK/ERK/CREB signaling (Blume et al., 2008; Yoshida et al., 2009). The gene discussed is MAP2K7; the disease is Anxiety.