Herein, to further investigate whether inhibition of HDMs could change NMS stress-induced OXTR expression through epigenetic modulation of histone methylation pathway and then alleviate the impairments in social recognition and autistic-like behaviors, we used a selective KDM5B inhibitor of AS-8351 (Zhang et al., 2019) to treat NMS rats on PND 21–35. This evidence concerns the gene KDM5B and neuroleptic malignant syndrome.