Incidentally, cyclooxygenase-2 (COX-2), by producing both free radicals and neuroinflammatory prostaglandins, plays a main role in AD pathogenesis and the administration of non-steroidal antinflammatory drugs (NSAIDs), including COX-2 inhibitors, has been considered a prophylactic approach to reduce the risk to develop AD (Hoozemans and O’Banion, 2005; Minghetti, 2007). Here, PTGS2 is linked to Alzheimer disease.