On these premises, the first aim of this work is to fully characterize, by using a pharmacological approach, the differential regulation of the HO/BVR system by both sAβ and fAβ in the human neuroblastoma SH-SY5Y cells, a reliable experimental system widely used to study neurodegeneration and AD (Marrazzo et al., 2019; Wang et al., 2019; Celik et al., 2020). This evidence concerns the gene SH3BP5 and Alzheimer disease.