Since HO-1 and BVR may undergo post-translational modifications in AD hippocampi which impair their enzymatic activities (Barone et al., 2011a,b, 2012b), a common strategy to preserve neuroprotection is to up-regulate HO-1 through the administration of some drugs (e.g., atorvastatin) or herb-derived antioxidants (e.g., ferulic acid, curcumin, rosmarinic acid, etc.)(Barone et al., 2012a; Butterfield et al., 2012; Catino et al., 2015; Fetoni et al., 2015; Mhillaj et al., 2018a, 2019). This evidence concerns the gene HMOX1 and Alzheimer disease.