PAD enzymes are highly conserved throughout evolution, in humans there are five main types of PAD genes (Chavanas et al., 2004) which display both tissue and substrate specificity and are involved in a plethora of physiological functions including tissue structure, apoptosis and immune regulation (Wegner et al., 2010), of note PAD2 and PAD4 are likely more important in RA development given their isolation in the synovium of RA patients (Foulquier et al., 2007). This evidence concerns the gene PADI2 and rheumatoid arthritis.