We hypothesize that this subset shift could relate to more severe COVID-19 outcomes in non-Hispanic Blacks, especially as the pro-inflammatory, non-classical (CD14+/CD16+) monocyte subset can play an important role in the inflammatory storm observed in severe COVID-19 (42) and has been postulated as potentially crucial in separating mild from severe COVID-19 cases (53). The gene discussed is CD14; the disease is COVID-19.