TP53 and familial pancreatic carcinoma: To verify whether inhibition of STRAP was effective against TP53-mutant pancreatic cancer cells by inhibiting snoRNA-mediated rRNA maturation, we successfully constructed STRAP-interfering stable cell lines based on p53 overexpression (Figure 5A and Supplementary Figure 3A) or p53-knockdown (Figure 6A and Supplementary Figure 4A).