TP53 and familial pancreatic carcinoma: Experiments in vitro and in vivo have shown that the proportion of mature 18S rRNA and 28S rRNA is significantly reduced in p53 overexpressed PANC-1 and Patu-8988 pancreatic cancer cell lines, and knockdown of p53 in KP4 and PANC-0327 pancreatic cancer cell lines promoted the maturation of 18S rRNA and 28S rRNA.