TP53 and cancer: Both in vitro and in vivo, knockdown of STRAP in the TP53 mutant state (Figures 5B–G and Supplementary Figures 3B–E) or p53-knockdown (Figures 6B–G and Supplementary Figures 4B–E) did indeed inhibit rRNA maturation and could effectively inhibit the development of cancer in vitro and in vivo, but there was no significant effect on the high p53 expression cell lines.