These results indicate that snoRNA-mediated rRNA maturation may be a possible mechanism for the progression of cancer in PDAC patients with TP53 mutations, but we believe that snoRNA-mediated rRNA maturation is not simply a surrogate for proliferation rate, other targets and pathways affecting the proliferation of TP53 mutant pancreatic cancer cells need further exploration, which is. This evidence concerns the gene TP53 and familial pancreatic carcinoma.