These results indicate that snoRNA-mediated rRNA maturation may be a possible mechanism for the progression of cancer in PDAC patients with TP53 mutations, but we believe that snoRNA-mediated rRNA maturation is not simply a surrogate for proliferation rate, other targets and pathways affecting the proliferation of TP53 mutant pancreatic cancer cells need further exploration, which is. This evidence concerns the gene TP53 and cancer.