Diniz et al. (25) recently evaluated by immunohistochemistry HE4 tissue expression in UCC, demonstrating that intraepithelial carcinomas and normal cervical epithelia had low or negative HE4 expression, while invasive UCC presented increased HE4 positivity, regardless of histological subtypes, consistent with the results obtained at the serum level in the present study. The gene discussed is WFDC2; the disease is in situ carcinoma.