PVT1 functions in close coordination with MYC and the intricate relationship between both genes was recently explained in a new study (70), which showed a PVT1 dependence for those cancers that have a copy-number increase of MYC. It is known that MYC is consistently co-gained with the adjacent genes PVT1, CCDC26, and GSDMC that lie within a region of about 2 Mb (70). This evidence concerns the gene PVT1 and cancer.