AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: In bone marrow samples from CML patients, the expression levels of HULC correlated positively with MYC and knockdown of HULC retarded the proliferation of CML leukemic cells and induced apoptosis by repressing MYC, Bcl-2 and by upregulating the PI3K/AKT signaling pathway (141).