Kluiver and his group (72) used the immortalized B cell line P493-6, which was engineered to express MYC in a tetracycline-repressible manner, and primary B-cell lymphoma samples from patients to show that lncRNAs are a main component of the MYC-regulated transcriptional program comparable to regular mRNAs and micro RNAs (miRNA). Here, MYC is linked to B-cell non-Hodgkin lymphoma.