MYC and acute promyelocytic leukemia: This causes a feed forward loop since the stabilization of MYC enhances the expression of MYC target genes among them also PVT1, which leads to even more active MYC. Support for this comes from studies with acute promyelocytic leukemia (APL) cell lines, where knockdown of PVT1 resulted in the downregulation of MYC whereas MYC silencing also reduced PVT1 levels, causing reduced proliferation (110).