In murine MLL-ENL AML models, depletion of Pvt1 together with two other lncRNAs, called Lilam (leukemia-induced lncRNA affecting Myc) and Pilna (progenitor-induced lncRNA neighboring Ak3), activated a myeloid differentiation program which was reversed by Myc overexpression showing an epistatic relationship between these three lncRNAs and Myc (111). The gene discussed is PVT1; the disease is acute myeloid leukemia.