Scott et al. proposed that GOLPH3, as a target of 5p13 amplification, could serve as a potent proto-oncogene in human cancers (11, 19), and found that overexpression of GOLPH3 could function with the retromer subunit VPS35, via the AKT/mTOR pathway, to promote cancer cell proliferation (11). Here, VPS35 is linked to cancer.