BRCA1 and breast cancer: The percentage of VUS, although relatively high, is comparable to that reported in other studies that included moderate and low-risk genes, such as the one published in 2018 by Xie et al. (37), which evaluated 100 women and found a VUS rate of 34.25% in 10 genes associated with susceptibility to breast cancer (excluding BRCA1 and BRCA2).