Although a significant correlation between the tumor glucose metabolism level captured on PET images and EGFR mutation status has been found in multiple previous studies (11–14), namely lower SUVmax in NSCLCs with EGFR mutation than those with wild type EGFR, conventional PET-derived semi-quantitative parameters didn’t show enough satisfactory predictive ability to be applied in clinical practice. Here, EGFR is linked to neoplasm.