In our study, pre-miR-124s (miR-124-1, miR-124-2 and miR-124-3) were upregulated in early recurrence B-ALL, and miR-124-3p was predicted to target the gene IFI44L. pre-miR-103a (miR-103a-2) and pre-miR-486 (miR-486-2), which target the genes HOXA7 and S100A10, respectively, were downregulated in patients who relapsed within 24 months. The gene discussed is IFI44L; the disease is acute lymphoblastic leukemia.