And several published articles showed that the biomarkers for early recurrence in B-ALL include the persistence of MRD, chromosome 19p13 translocations, upregulation of nucleotide excision repair genes, deletion of CDKN2A/B and overexpression of LINC00152 (Supplementary Table S1) (20–24). Here, CDKN2A is linked to acute lymphoblastic leukemia.