In view of MFs, these DMGs involved in protein binding, peptidyl-prolyl cis-trans isomerase activity, identical protein binding and poly (A) RNA binding, etc. For example, the etiology of early-onset CRC was linked to ploy (A) RNA binding endorsed by a set of hub genes (39) and the metastasis of breast cancer resulted from LSD1 demethylation (40). Here, KDM1A is linked to breast carcinoma.