By contrast, the multivariate cox analysis revealed 12 DMGs (CETN3, DCAF7, GPX4, HNRNPA0, NUP54, SERPINB1, STARD5, TRIM52, C4orf3, C12orf51, C17orf65, and C21orf45) significantly affected overall survival of ccRCC patients (Table 1). The gene discussed is SERPINB1; the disease is nonpapillary renal cell carcinoma.