Further, we added OA (oleate) into ESCC cells (Supplementary Figure 4A), and the results showed that OA promoted ESCC cell proliferation, migration, and invasion, whereas knockdown of HNRNPA2B1 inhibited OA-induced the malignant process (Figures 8E,F). The gene discussed is HNRNPA2B1; the disease is esophageal squamous cell carcinoma.