Next, we detected the major enzymes involved in de novo fatty acid synthesis, fatty acid β-oxidation and fatty acid uptake, revealing that de novo fatty acid synthetic enzymes ACLY, and ACC1 were markedly decreased when knockdown of HNRNPA2B1 in both two ESCC cells (Figure 8B). The gene discussed is HNRNPA2B1; the disease is esophageal squamous cell carcinoma.