Meanwhile, the article showed that KD-HNRNPC could up regulate many other genes like MAP3K3 and MTF2 which were reported to be associated with a bad prognosis, respectively, in Hepatocellular Carcinoma and ovarian carcinoma and downregulated other genes like DNAJA3 which was proved to be associated with the increasing of overall survival in breast cancer (41–43). The gene discussed is MAP3K3; the disease is breast cancer.