Transcriptome sequencing was performed in 86 patients with Ph-like ALL. Genetic alterations were identified in 88% of patients. CRLF2-51%, JAK2/EPOR-12.4%, other JAK-STAT seq. mutation-7.2%, ABL class fusion-9.8%, RAS pathway mutation-3.6%, other kinase-4.1%, and no kinase-4.6%. This evidence concerns the gene CRLF2 and acute lymphoblastic leukemia.