CRLF2 and acute lymphoblastic leukemia: It is highly prevalent in Hispanic patients due to presence of germline variant GATA3 in Hispanic and native American genetic ancestry, particularly common with Ph-like ALL with cytokine receptor like factor two-rearrangement (CRLF2-R). Ph-like ALL is a frequently occurring subtype in pediatric and young adults, and is associated with poor response to induction chemotherapy, elevated WBC count, high levels of MRD.