It is highly prevalent in Hispanic patients due to presence of germline variant GATA3 in Hispanic and native American genetic ancestry, particularly common with Ph-like ALL with cytokine receptor like factor two-rearrangement (CRLF2-R). Ph-like ALL is a frequently occurring subtype in pediatric and young adults, and is associated with poor response to induction chemotherapy, elevated WBC count, high levels of MRD. Here, CRLF2 is linked to acute lymphoblastic leukemia.