Kinome capture and RNA seq. were performed in 160 patients with Ph-like ALL (129 with CRLF2 low and 31 with CRLF2 high but lacking CRLF2 rearrangement). Genetic alterations were identified in 83.8% of patients. CRLF2- 43.7%, JAK2 and EPOR- 8.8%, other JAK-STAT seq. Mutation-4.6%, ABL class fusion-14.1%, RAS pathway mutation-6%, other kinases-4.6% and no kinase is ~15%. Here, CRLF2 is linked to acute lymphoblastic leukemia.