Ph-like ALL has a gene expression profile similar to BCR-ABL1 but lacks BCR-ABL1 expression [9]. The Hallmark of Ph-like ALL is the high frequency of IKAROS family zinc finger one (IKZF1) alteration that is 70%-80% as compared to non-Ph-like ALL that is 15%. The gene discussed is IKZF1; the disease is acute lymphoblastic leukemia.