In the lean animals, adipocyte Fpn deletion using a mouse model of AP2 Cre and Fpnfl/fl caused systemic glucose intolerance by downregulating the production of adiponectin through decreased acetylation of FOXO1 and a co-repressive effect by FOXO1’s binding to a PPARγ response element [38]. Here, ADIPOQ is linked to Glucose intolerance.