In the present study the frequency of hyperlipidemia, obesity, hypertension, metabolic syndrome and elevated RBP-4 level was higher in hypothyroid patients with positive parental history of CAD than those with negative history, therefore increased RBP-4 in hypothyroid patients with positive parental history of CAD may be the cause of increased risk factors [32,33]. The gene discussed is RBP4; the disease is metabolic syndrome.