All the related risk factors (except T4 and HDL-cholesterol) in hypothyroidism were significantly associated with RBP-4 when estimated adopting the spearman's coefficient: TSH r = 0.389, p = 0.003, fasting insulin r = 0.583, p = 0.001, insulin resistance r = 0.639, p = 0.001, fasting blood sugar r = 0.289, p = 0.028, total serum cholesterol r = 0.414, p = 0.001, serum triglyceride r = 0.589, p = 0.001, LDL-Ch r = 0.484 p = 0.001, LDL/HDL r = 0.521 p = 0.001, Hs-CRP r = 0.505 p = 0.001, MDA r = 0.411 p = 0.001. The gene discussed is C4B; the disease is Insulin resistance.