In insulin resistant state, the expression of GLUT-4 (the principal insulin-stimulated-glucose-transporter), is down regulated selectively in adipocytes and not in skeletal muscle; this result in impaired insulin stimulated glucose transport in adipocytes and this defect precedes glucose intolerance, however, the consequences of decreased GLUT-4 expression in adipocyte have been unclear, since adipose tissues contribute little to whole body glucose disposal [8,21,22]. The gene discussed is SLC2A4; the disease is Glucose intolerance.