Also, this isoflavone at the doses of 20 and 40 μmol/L reduced the expressions of MMP‐2 and MMP‐9 via PI3K/Akt signaling pathway in TNBC cell lines (MDA‐MB‐231 and 4T1) and inhibited the invasiveness of these BC cells (Zhou et al., 2014). This evidence concerns the gene MMP2 and breast cancer.