SIRT‐1 was shown to inhibit the proliferation and metastasis of gastric cancer cells through activating the STAT3/MMP‐13 signaling pathway by inducing phosphorylation/acetylation of matrix metalloproteinase 13 (MMP‐13) and STAT3 in both in vivo and in vitro models (Zhang et al., 2019). This evidence concerns the gene STAT3 and gastric cancer.