In other words, IL‐17 by activating P53 causes the stabilization of the PAI‐1, which in turn mediates the accumulation of extracellular matrix (ECM) and subsequent development of pulmonary fibrosis in alveolar type II (ATII) cells, and curcumin inhibits IL‐17A‐mediated changes in the p53‐fibrinolytic system (Figure 3) (Gouda & Bhandary, 2018, 2019). The gene discussed is IL17A; the disease is pulmonary fibrosis.