FCER1A has been shown to be expressed in mast cells and basophils as well as in monocytes and dendritic cells, and it has been suggested to have a dual role in IgE‐signaling – studies conducted using transgenic mouse models have shown that on one hand, FCER1A expression induces type 2 inflammation in the lungs after viral infection, on the other hand it has been linked to regulatory role in asthma, promoting immune homeostasis (reviewed in [97 ]). The gene discussed is IGHE; the disease is asthma.