After our GWAS catalogue search, a GWAS publication of Islandic and English CRS patients and controls showed that a missense variant in ALOX15 causing p.Thr560Met alteration in arachidonate 15‐lipoxygenase (15‐LO ) confers large genome‐wide significant protection against CRSwNP and CRS. The gene discussed is ALOX15; the disease is chronic rhinosinusitis with nasal polyps.