These pathways are implicated in various neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis), ocular diseases (e.g., glaucoma, diabetic retinopathy and age-related macular degeneration [AMD]), and immunologic disorders.[1,2,3,4,5,6] While treatments for the wet form of AMD rely on inhibiting choroidal neovascularization via anti-vascular endothelial growth factor (anti-VEGF) injections,[7] there is currently no cure for the dry form of AMD. The gene discussed is VEGFA; the disease is early-onset autosomal dominant Alzheimer disease.