During obesity, adipocytes undergo hypertrophy that leads to an increase of adipose tissue size followed by hypoxia conditions, which contribute to the secretion of proinflammatory adipokines, such as TNFα, TGFβ, IL-6, and MCP-1 by adipocytes and other cells present in adipose tissue [7–13]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.