We used the GEO database to obtain 527 CIS-related targets and obtained 12 intersection targets by taking the intersection with the XXMD targets, namely CD14, PTGS2, STAT1, CYP1B1, AKR1C3, AKR1B1, HMGCR, STAT3, MMP9, HIF1A, CD40LG, and HK2. This evidence concerns the gene AKR1C3 and in situ carcinoma.