RORC and psoriasis: While the prominent role of RORC in psoriasis as the major controller of Th17 cell differentiation is well described, however, the evidence of RORC expression in psoriasis is controversial and supported by work where mice T cells and dendritic cells had increased STAT3/RORC expression [48]; still, patients with psoriasis had elevated level of RORC (RORG-t isoform) [49].