Meanwhile, emerging reports suggest a relationship between HCC and thyroid hormone (TH) signaling (dysfunction), raising the possibility that perturbed TH regulation influences the liver microenvironment and HCC formation (Manka et al., 2018), so that these pathways are related to HCC regulated by sorafenib on some levels, and they all deserve further investigation in depth. The gene discussed is TH; the disease is hepatocellular carcinoma.