This was the case for the identification of CYP27A1 (cytochrome P450, subfamily XXVIIA, polypeptide 1), LIPA (lysosomal lipase A), LIPC (hepatic lipase), LIPG (endothelial lipase), CYP7A1 (cytochrome P450 family 7 subfamily A member 1), PNPLA5 (patatin-like phospholipase domain containing 5) and some other gene variants responsible for the FH phenotype in particular families (Lange et al., 2014; Al-Allaf et al., 2015; Pirillo et al., 2017; Corral et al., 2018; Mikhailova et al., 2019; Table 3). Here, CYP7A1 is linked to familial hyperaldosteronism.