Thus, based on the consensus of the American College of Medical Genetics (ACMG), the ClinVar initiative has been established to determine the likely pathogenicity of variants in LDLR/APOB/PCSK9 genes reported in patients with clinical FH (Richards et al., 2015; Iacocca et al., 2018). The gene discussed is PCSK9; the disease is familial hyperaldosteronism.