The GSEA result revealed many significant cancer-related pathways for the RBP signature, of which the insulin signaling pathway, ERBB signaling pathway, renal cell carcinoma, pathways in cancer, MTOR signaling pathway, WNT signaling pathway, TGF BETA signaling pathway, and UBIQUITIN mediated proteolysis were enriched in the low-risk group, and no significant pathway was enriched in the high-risk group. The gene discussed is INS; the disease is cancer.