It has been reported that several m6A regulators including METTL3 (Chen et al., 2018), METTL14 (Ma et al., 2017), WTAP (Chen et al., 2019), KIAA1429 (Lan et al., 2019), and YTHDF2 (Hou et al., 2019), play critical roles in the carcinogenesis and progression of HCC. Here, METTL3 is linked to hepatocellular carcinoma.