Considering the vital function of APC/C in eukaryotic cells mitosis (Pines, 2011), ANAPC7 might play an essential role in fulvestrant resistance, and ANAPC7 (anaphase-promoting complex subunit 7) was expected to be a novel biomarker or therapeutic target for fulvestrant-resistant breast cancer. The gene discussed is ANAPC7; the disease is breast carcinoma.