ESR1 and cancer: Kyoto Encyclopedia of Gene and Genome pathway enrichment analysis demonstrated that ER might regulate genes along pathways associated with cancer, progesterone-mediated oocyte maturation, RNA transport, glycerophospholipid and glycerolipid metabolism, oocyte meiosis, platelet activation, phosphatidylinositol signaling system, estrogen signaling pathway, and nuclear factor κB (NF-κB) signaling pathway (P < 0.05).