TP53 and hepatocellular carcinoma: For instance, DNA replication is associated with tumor cell proliferation and the prognosis of HCC (Xie et al., 2018), variations in cell cycle pathway genes affect disease-free survival of patients with HCC (Liu et al., 2017), TP53 mutation is considered one of the critical molecular mechanisms of HCC pathogenesis (Hussain et al., 2007), an abnormal cellular senescence phenotype is observed in various cancer types (Chen S. L. et al., 2019), and cytochrome P450 is severely damaged and dysregulated in HCC (Yan et al., 2015).