As shown in Supplementary Table 7, specific pathways, such as cell cycle, and p53 signaling, were highlighted, both of which are closely related to tumorigenesis and the development of HCC (Hussain et al., 2007; Sanchez-Vega et al., 2018; Ikeno et al., 2019). The gene discussed is TP53; the disease is hepatocellular carcinoma.